Rodrigo, Joe, Melissa, and Chelsea's paper is published in the Journal of Chemical Education!
Acoustogenic Probes: A Demonstration to Introduce the Photoacoustic Effect via Analyte Sensing
Photoacoustic imaging is a state-of-the-art technique that combines light excitation with ultrasound generation via the photoacoustic effect. Since sound waves at clinically relevant frequencies undergo minimal perturbation as they pass through the body, photoacoustic imaging is ideal for deep-tissue imaging applications in vivo. Despite its utility in the biomedical field, it is unlikely that undergraduate students will ever experience this technology firsthand in a classroom setting owing to the delicate and expensive nature of the instrumentation. Likewise, students will not be exposed to acoustogenic probes, which are specialized chemicals designed to detect biologically relevant analytes using photoacoustic imaging. With the goal of introducing new chemical analysis and imaging techniques to the undergraduate chemistry curricula, we present a simple and inexpensive setup (all materials were purchased for less than $48 USD) to demonstrate the photoacoustic effect through analyte sensing