Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform
Nitric oxide (NO) is a key signaling molecule involved in a variety of physiological and pathological processes. Over the past few decades it has become clear that the microenv...
A photoactivatable formaldehyde donor with fluorescence monitoring reveals threshold to arrest cell migration
Controlled light-mediated delivery of biological analytes can enable the investigation of highly reactivity molecules within living systems. As many biological...
An activity-based sensing approach for the detection of cyclooxygenase-2 in live cells
Cyclooxygenase‐2 (COX‐2) overexpression is prominent in inflammatory diseases, neurodegenerative disorders, and cancer. Directly monitoring COX‐2 activity within its native environmen...
Lukas successfully passed his PhD defense and became the very Chan Lab member to complete his PhD! After leaving UIUC, Lukas plans to return home to Germany and start his next big adventure. Congratulations Lukas, we will miss you!
Rational Design of a Red Fluorescent Sensor for ALDH1A1 Displaying Enhanced Cellular Uptake and Reactivity
High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. To facilitate the...
Three Chan Lab undergrads presented their research at the 2019 ECI ACS Undergraduate Research Conference. Irian was selected to present an oral presentation and gave an outstanding talk, and Douglas and Lupe both received outstanding poster awards for their poster pres...
A Conformationally Restricted Aza-BODIPY Platform for Stimulus-Responsive Probes with Enhanced Photoacoustic Properties
Photoacoustic (PA) dyes, which absorb near-infrared (NIR) light to generate an ultrasonic signal, can be detected at centimeter depths in tissues with...
We are excited to announce that Joe Forzano has joined the Chan Lab!
Brief bio: Joe is from Ludlow, MA and graduated from Colby College with a BA in Chemistry with ACS Certification. His undergraduate research focused on the synthesis of novel macrocycles and studying t...
We are excited to welcome Rodrigo Tapia Hernandez to the Chan Lab!
Brief bio: Rodrigo received his BS in chemistry from Augsburg University in the spring of 2019. His undergraduate research focused on understanding the chemical interactions of functionalized nanoparticl...
We are excited to announce that Selena Hernandez has joined the Chan Lab!
Brief bio: Selena graduated with a BS in Chemistry from UCLA. She began her undergraduate research career in medicinal chemistry, where she synthesized a library of ribonucleotide reductase inhibi...
