29. Brady CJ, Lee MC, Ibarra GE, Chan J. New frontiers in molecular imaging for drug development. Chem. 2020, in preparation.

28. Hernandez RT, Forzano JA, Lucero MY, Anorma C, Chan J. Acoustogenic probes: An interactive activity to demonstrate analyte sensing via the photoacoustic effect. J. Chem. Educ. 2020, in preparation.

27. East AK, Lucero MY, Chan J. New directions in activity-based sensing for in vivo near-infrared imaging. Chem. Sci. 2020, accepted. article

26. Yadav AK, Hernandez S, Su S, Chan J. Acoustic-based chemical tools for profiling the tumor microenvironment. Curr. Opin. Chem. Biol. 2020, accepted. 

25. Lucero MY, Chan J. Towards personalized medicine: Photoacoustic imaging of glutathione enables companion diagnosis and targeted treatment of lung cancer. 2020, in review. ChemRxiv Preprint 

24. Alanagh HR, Fathi P, Knox HJ, Chan J, Pan D. Molecular interactions of Cu- and Fe-based metal organic frameworks with biliverdin: A combined photoacoustic, fluorescence, and in vitro study. Nanoscale 2020, in review.

23. Gardner SH, Reinhardt CJ, Chan J. Advances in activity-based sensing probes for isoform-selective imaging of enzymatic activity. Angew. Chem. Int. Ed. 2020, accepted. article

22. Yu ZH, Reinhardt CJ, Hin-Fung T, Chan J, Au-Yeung HY. Activity-based ascorbate sensing using a copper-mediated oxidative bond cleavage. Chem. Eur. J. 2020, 26, 8794-8800. article

21. Reinhardt CJ, Xu R, Chan J. Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform. Chem. Sci. 2020, 11, 1587-1592. article

20. Smaga LP, Pino NW, Ibarra GE, Krishnamurthy V, Chan J. A photoactivatable formaldehyde donor with fluorescence monitoring reveals threshold to arrest cell migration. J. Am. Chem. Soc. 2020, 142, 680-684. article ChemRxiv Preprint

19. Yadav AK, Reinhardt CJ, Arango AS, Huff HC, Dong L, Malkowski MG, Das A, Tajkhorshid E, Chan J. An activity-based sensing approach for the detection of cyclooxygenase-2 in live cells. Angew. Chem. Int. Ed. 2020, 59, 3307-3314. article Beckman News NSF Research News

18. Hedhli J, Kim MW, Knox HJ, Cole JA, Huynh T, Schuelke M, Dobrucki IT, Kalinowski L, Chan J, Sinusas AJ, Insana MF, Dobrucki LW. Imaging the landmarks of vascular recovery. Theranostics 2020, 10, 1733-1745. article Inside Front Cover Illinois News Bureau

17. Bearrood TE, Aguirre-Figueroa G, Chan J. Rational design of a red fluorescent sensor for ALDH1A1 displaying enhanced cellular uptake and reactivity. Bioconjug. Chem. 2020, 31, 224-228. article Molecular Imaging Special Issue

16. Zhou EY, Knox HJ, Liu C, Zhao W, Chan J. A conformationally-restricted aza-BODIPY platform for stimulus-responsive probes with enhanced photoacoustic properties. J. Am. Chem. Soc. 2019, 141, 17601-17609. article JACS Spotlights

15. Chen M, Knox HJ, Liu W, Tang Y, Chan J, Yao J. Simultaneous photoacoustic imaging of hemodynamic and tissue hypoxia. Opt. Lett. 2019, 44, 3373-3776. article OSA Editor's Pick

14. Fathi P, Knox HJ, Sar D, Tripathi I, Misra SK, Ostadhossein F, Esch MB, Chan J, Pan D. Biodegradable biliverdin nanoparticles for efficient photoacoustic imaging. ACS Nano. 2019, 13, 7690-7704. article Beckman News

13. Knox HJ, Chan J. Acoustogenic probes: A new frontier in photoacoustic imaging. Acc. Chem. Res. 2018, 51, 2897-2905. article Activity-Based Sensing Special Issue

12. Zhou EY, Knox HJ, Reinhardt CJ, Partipilo G, Nilges M, Chan J. Near-infrared photoactivatable nitric oxide donors with integrated photoacoustic monitoring. J. Am. Chem. Soc. 2018, 140, 11686-11697. article

11. Anorma C, Hedhli J, Bearrood TE, Pino NW, Gardner SH, Inaba H,  Zhang P, Li Y, Feng D, Dibrell SE, Kilian KA, Dobrucki LW, Fan TM, Chan J. Surveillance of cancer stem cell plasticity using an isoform-selective fluorescent probe for aldehyde dehydrogenase 1A1. ACS Cent. Sci. 2018, 4, 1045-1055. article ACS LiveSlides Illinois News Bureau Medical News Biocompare Photonics

10. Knox HJ, Kim TW, Zhu Z, Chan J. Photophysical tuning of N-oxide-based probes enables ratiometric photoacoustic imaging of tumor hypoxia. ACS Chem. Biol. 2018, 13, 1838-1843. article Sensors Special Issue

9. Geng JL, Li W, Smaga LP, Sottos NR, Chan J. Damage-responsive microcapsules for amplified photoacoustic detection of microcracks in polymers. Chem. Mater. 2018, 30, 2198-2202. article ACS Editors Choice C&EN     

8. Reinhardt CJ, Zhou EY, Jorgensen MD, Partipilo G, Chan J. A ratiometric acoustogenic probe for in vivo imaging of endogenous nitric oxide. J. Am. Chem. Soc. 2018, 140, 1011-1018. article

7. Reinhardt CJ, Chan J. Development of photoacoustic probes for in vivo molecular imaging. Biochemistry. 2018, 57, 194–199. article Future of Biochemistry Special Issue

6. Pino NW, Davis III J, Yu Z, Chan J. NitroxylFluor: A thiol-based fluorescent probe for live-cell imaging of nitroxyl (HNO). J. Am. Chem. Soc. 2017, 139, 18476-18479. article

5. Knox HJ, Hedhli J, Kim TW, Khalili K, Dobrucki L, Chan J. A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia. Nat. Commun. 2017, 8, 1794-1802. article Biochemistry Viewpoint C&EN Illinois News Bureau Phys.Org AAAS My Science Medical News Technology Breaking News

4. Bearrood TE, Chan J. Disproportionate impact of named reactions on chemical biology. Aldrichimica Acta. 2017, 50, 31-42. article

3. Zhang JJ, Smaga LP, Satyavolu NSR, Chan J, Lu Y. DNA aptamer-based activatable probes for photoacoustic imaging in living mice. J. Am. Chem. Soc. 2017, 139, 17225–17228. article JACS Spotlights

2. Li H, Zhang P, Smaga LP, Hoffman RA, Chan J. Photoacoustic probes for ratiometric imaging of copper(II). J. Am. Chem. Soc. 2015, 137, 15628-15631. article X-MOL

1. Roth A, Li H, Anorma C, Chan J. A reaction-based fluorescent probe for imaging of formaldehyde in living cells. J. Am. Chem. Soc. 2015, 137, 10890-10893. article C&EN X-MOL

Patents Filed at Illinois

4. Chan J, Reinhardt CJ, Yadav AK. Fluorescent probe for cyclooxygenase-2. 2020, U.S. Patent Application No.: 63/015,164.

3. Chan J, Bearrood TE, Anorma C. Selective fluorescent probe for aldehyde dehydrogenase. 2020, US20200199092A1. article

2. Chan J, Pino NW. Thiol-based fluorescent probe for reactive species. 2020, US20200140452A1. article

1. Chan J, Knox HJ. Bioreducible N-oxide-based probes for imaging of hypoxia. 2020, US20200062784A1. article

Book Chapters

1. Zhou EY, Knox HJ, Reinhardt CJ, Partipilo G, Chan J. Near-infrared photoactivatable nitric oxide donors with photoacoustic readout. Methods in Enzymology, 2020, 641, 113-147. book chapter

Before Illinois

25. Xiao T, Ackerman CM, Carroll EC, Jia S, Hoagland A, Chan J, Thai B, Liu CS, Isacoff EY, Chang CJ. Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Nat. Chem. Biol. 2018, 14, 655–663. article

24. Ladomersky E, Khan A, Shanbhag V, Cavet JS, Chan J, Weisman GA, Petris MJ. Host and pathogen copper-transporting P-type ATPases function antagonistically during Salmonella infection. Infect. Immun. 2017, 85, e00351-17. article

23. Chun H, Sharma AK, Lee J, Chan J, Jia S, Kim B-E. The intestinal copper exporter CUA-1 is required for systemic copper homeostasis in Caenorhabditis elegans. J. Biol. Chem. 2017, 292, 1-14. article

22. Krishnamoorthy L, Cotruvo Jr JA, Chan J, Kaluarachchi H, Muchenditsi A, Pendyala VS, Jia S, Aron AT, Ackerman CM, Vander Wal MN, Guan T, Smaga LP, Farhi SL, New EJ, Lutsenko S, Chang CJ. Copper regulates cyclic-AMP-dependent lipolysis. Nat. Chem. Biol. 2016, 12, 586–592. article

21. Nantasanti S, Spee B, Kruitwagen HS, Chen C, Geijsen N, Oosterhoff LA, van Wolferen ME, Pelaez N, Fieten H, Wubbolts RW, Grinwis GC, Chan J, Huch M, Vries RRG, Clevers H, de Bruin A, Rothuizen J, Penning LC, Schotanus BA. Disease modelling and gene therapy of copper storage disease in canine hepatic organoids. Stem Cell Reports 2015, 5, 895-907. article


20. Chan J, Tang A, Bennet AJ. Transition-state structure for the hydronium ion-promoted hydrolysis of α-D-glucopyranosyl fluoride. Can J Chem 2015, 93, 463-467. article


19. Dodani SC,* Firl A,* Chan J,* Nam CI, Aron AT, Onak CS, Ramos-Torres KM, Paek J, Webster CM, Feller MB, Chang CJ. Copper is an endogenous modulator of neural circuit spontaneous activity. PNAS 2014, 111, 16280-1625. [* = equal contribution] article


18. Hong-Hermesdorf A, Miethke M, Gallaher SD, Kropat J, Dodani SC, Chan J, Barupala D, Domaille DW, Shirasaki DI, Loo JA, Weber PK, Pett-Ridge J, Stemmler TL, Chang CJ, Merchant SS. Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas. Nat. Chem. Biol. 2014, 10, 1034-1042. article


17. Chan J, Sannikova N, Tang A, Bennet J. Transition-state structure for the quintessential SN2 reaction of a carbohydrate: Reaction of α-glucopyranosyl fluoride with azide ion in water. J. Am. Chem. Soc. 2014, 136, 12225-12228. article


16. Kashyap DR, Rompca A, Gaballa A, Helmann JD, Chan J, Chang CJ, Gupta D, Dziarski R. Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress. PLoS Pathog. 2014, 10, 1-17. article


15. Polishchuk EV, Concilli M, Iacobacci S, Chesi G, Pastore N, Piccolo P, Paladino S, Baldantoni D, van IJzendoorn SCD, Chan J, Chang CJ, Amoresano A, Pane F, Pucci P, Tarallo A, Parenti G, Brunetti-pierri N, Settembre C, Ballabio A, Polishchuck RS. Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis. Dev. Cell. 2014, 29, 686-700. article


14. Chan J, Chang CJ. Making light of stress. Nat. Biotechnol. 2014, 32, 337-338. article


13. Huang CP, Fofana M, Chan J, Chang CJ, Howell SB. Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin. Metallomics 2014, 6, 654-661. article


12. Hao Z, Lou H, Zhu R, Zhu J, Zhang D, Zhao BS, Zeng S, Chen X, Chan J, He C, Chen PR. The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli. Nat. Chem. Biol. 2014, 10, 21-28. article


11. Au-Yeung HY, Chan J, Chantarojsiri T, Chang CJ. Molecular imaging of labile iron(II) pools in living cells with a turn-on fluorescent probe. J. Am. Chem. Soc. 2013, 135, 15165–15173. article


10. Chan J, Dodani SC, Chang CJ. Reaction-based small-molecule fluorescent probes for chemoselective bioimaging. Nat. Chem. 2012, 2, 973–984. article


9. Macauley MS, Chan J, Zandberg W, He Y, Whitworth GA, Stubbs KA, Yuzwa SA, Bennet AJ, Varki A, Davies GJ, Vocadlo DJ. Metabolism of vertebrate amino sugars with N-glycolyl groups: Intracellular O-GlcNGc, UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of O-GlcNAcase. J. Biol. Chem. 2012, 287, 28882–28897. article


8. Chan J, Lewis AR, Indurugalla D, Schur M, Wakarchuk W, Bennet AJ. Transition state analysis of Vibrio cholerae sialidase-catalyzed hydrolyses of natural substrate analogues. J. Am. Chem. Soc. 2012, 134, 3748–3757. article


7. Chan J, Tang A, Bennet AJ. A stepwise solvent-promoted SNi reaction of α-D-glucopyranosyl fluoride: mechanistic implications for retaining glycosyltransferases. J. Am. Chem. Soc. 2012, 134, 1212–1220. article


6. Chan J, Watson JN, Lu A, Borgford TJ, Bennet AJ. Bacterial and viral sialidases: Contribution of the conserved active site glutamate to catalysis. Biochemistry 2012, 51, 433–441. article


5. Chan J, Bennet AJ. "Enzymology of influenza virus sialidase" in  Influenza Virus Sialidase - A Drug Discovery Target, M. Von Itzstein (ed); Springer: New York, 2012, 47-66. article


4. Chan J, Sandhu G, Bennet AJ. A mechanistic study of sialic acid mutarotation: Implications for mutarotase enzymes. Org. Biomol. Chem. 2011, 9, 4818–4822. article


3. Chan J, Lu A, Bennet AJ. Turnover is rate-limited by deglycosylation for Micromonospora viridifaciens sialidase-catalyzed hydrolyses: Conformational implications for the Michaelis complex. J. Am. Chem. Soc. 2011, 133, 2989–2997. article


2. Telford JC, Yeung JHF, Xu G, Kiefel MJ, Watts AG, Hader S, Chan J, Bennet AJ, Moore MM, Taylor GL. The Aspergillus fumigatus sialidase is a 3-deoxy-d-glycero-d-galacto-2-nonulosonic acid hydrolase (KDNase): Structural and mechanistic insights. J. Biol. Chem. 2011, 286, 10783–10792. article


1. Chan J, Lewis AR, Gilbert M, Karwaski M-F, Bennet AJ. A direct NMR method for the measurement of competitive kinetic isotope effects. Nat. Chem. Biol. 2010, 6, 405–407. article


Patents Before Illinois

2. Homoallylamines as formaldehyde-responsive triggers. 2017, WO2017034927A1. article

1. Fluorescent probes for detection of copper. 2014, US20140051863A1. article

© #CHANLAB 2020.

  • w-facebook
  • Twitter Clean