Hailey, Jamila, Tom and Kian's paper is accepted in Nature Communications!

October 25, 2017

A Bioreducible N-oxide-based Probe for Photoacoustic Imaging of Hypoxia

 Hypoxia occurs when limited oxygen supply impairs physiological functions and is a pathological hallmark of many diseases including cancer and ischemia. Thus, detection of hypoxia can guide treatment planning and serve as a predictor of patient prognosis. Unfortunately, current methods suffer from invasiveness, poor resolution and low specificity. To address these limitations, we present Hypoxia Probe 1 (HyP-1), a hypoxia-responsive agent for photoacoustic imaging. This emerging modality converts safe, non-ionizing light to ultrasound waves, enabling acquisition of high-resolution 3D images in deep tissue. HyP-1 features an N-oxide trigger that is reduced in the absence of oxygen by haem proteins such as CYP450 enzymes. Reduction of HyP-1 produces a spectrally distinct product, facilitating identification via photoacoustic imaging. HyP-1 exhibits selectivity for hypoxic activation in vitro, in living cells and in multiple disease models in vivo. HyP-1 is also compatible with NIR fluorescence imaging, establishing its versatility as a multimodal imaging agent.




Please reload

Featured Posts

Effie, Hailey, and Chris's book chapter is accepted for publication in Methods in Enzymology!

June 22, 2020

Please reload

Recent Posts
Search By Tags

June 15, 2020

Please reload

Please reload

Follow Us
  • Facebook Classic
  • Twitter Classic
  • Google Classic

© #CHANLAB 2020.

  • w-facebook
  • Twitter Clean