Hao, Pam, Lukas and Ryan's paper is published in JACS!
December 8, 2015
Photoacoustic Probes for Ratiometric Imaging of Copper(II)
Photoacoustic tomography has emerged as a promising alternative to MRI and X-ray scans in the clinical setting due to its ability to afford high-resolution images at depths in the cm range. However, its utility has not been established in the basic research arena owing to a lack of analyte-specific photoacoustic probes. To this end, we have developed APC-1 (Acoustogenic Probe for Copper(II)-1) and APC-2, a water-soluble congener, for the chemoselective visualization of Cu(II), a metal ion which plays a crucial role in chronic neurological disorders such as Alzheimer’s disease. To detect Cu(II), we have equipped both APCs with a 2-picolinic ester sensing module that is readily hydrolyzed in the presence of Cu(II) but not by other divalent metal ions. Additionally, we designed APC-1 and APC-2 explicitly for ratiometric photoacoustic imaging by using an aza-BODIPY dye scaffold exhibiting two spectrally resolved NIR absorbance bands which correspond to the 2-picolinic ester capped and uncapped phenoxide forms. The normalized ratiometric turn-on responses for APC-1 and APC-2 were 89- and 101-fold, respectively.
Chris successfully defended his thesis!
June 19, 2020
Anuj and Chris's paper is published in Angewandte Chemie!
December 18, 2019
Effie, Hailey, and Chris's book chapter is accepted for publication in Methods in Enzymology!