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Sarah Gardner

BS in Biochemistry from the University of Iowa

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PhD Student in Biochemistry

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Publications

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10. Cheng J, Bo Y, Zhou J, Cai K, Wang Y, Feng Y, Li W, Jiang Y, Kuo S, Roy J, Anorma C, Gardner SH, Luu LM, Lau G, Chan J, Wang H. Leveraging intracellular ALDH1A1 activity for selective cancer stem-like cells labeling and targeted treatment via click reaction. PNAS 2023, In-Press.

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9. Lee MC,* Gardner SH,* Tapia Hernandez R, Chan J. Application of AlDeSense to stratify ovarian cancer cells based on aldehyde dehydrogenase 1A1 Activity. JoVE 2023, 193, e64713.

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8. Yadav AK, Zhao Z, Weng Y, Gardner SH, Brady CJ, Pichardo Peguero OD, Chan J. Hydrolysis-resistant ester-based linkers for development of activity-based NIR bioluminescence probes. J. Am. Chem. Soc. 2023, 145, 2, 1460–1469.

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7. Lucero MY,* Gardner SH,* Yadav AK, Borri A, Zhao Z, Chan J. Activity-based photoacoustic probes reveal elevated intestinal MGL and FAAH activity in a murine model of obesity. Angew. Chem. Int. Ed. 2022, 61, e202211774.

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6. Li J, Dong Y, Wei R, Jiang G, Yao C, Lv M, Wu Y, Gardner SH, Zhang F, Lucero MY, Huang J, Chen H, Ge G, Chan J, Chen J, Sun H, Luo X, Qian X, and Yang Y. Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging. J. Am. Chem. Soc. 2022, 144, 14351. 

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5. Gardner SH,* Brady CJ,* Keeton C, Yadav AK, Mallojjala SC, Lucero MY, Su S, Yu Z, Hirschi JS, Mirica LM, Chan J. A general approach to convert hemicyanine dyes into highly optimized photoacoustic scaffolds for analyte sensing. Angew. Chem. Int. Ed. 2021, 60, 18860–18866.

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4. Gardner SH, Reinhardt CJ, Chan J. Advances in activity-based sensing probes for isoform-selective imaging of enzymatic activity. Angew. Chem. Int. Ed., 2021, 60, 5000–5009. 

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3. Laird JG, Gardner SH, Kopel AJ, Kerov V, Lee A, Baker SA. Rescue of rod synapses by induction of Cav alpha 1F in the mature Cav1.4 knock-out mouse retina. Invest. Ophthalmol. Vis. Sci. 2019, 60, 3150-3161.

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2. Anorma C, Hedhli J, Bearrood TE, Pino NW, Gardner SH, Inaba H,  Zhang P, Li Y, Feng D, Dibrell SE, Kilian KA, Dobrucki LW, Fan TM and Chan J. Surveillance of cancer stem cell plasticity using an isoform-selective fluorescent probe for aldehyde dehydrogenase 1A1. ACS Cent. Sci. 2018, 4, 1045-1055.

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1. Kerov V, Laird JG, Joiner M-L, Knecht S, Soh D, Hagen J, Gardner SH, Gutierrez W, Yoshimatsu T, Bhattarai S, Puthussery T, Artemyev NO, Drack AV, Wong RO, Baker SA and Lee A. α2δ-4 is required for the molecular and structural organization of rod and cone photoreceptor synapses. J. Neurosci. 2018,  38, 6145-6160.

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Select Awards

5. ACS Division of Biological Chemistry Travel Grant (2022)

4. Biochemistry Travel Grant (2021)

3. CCIL Graduate Cancer Scholarship (2021)

2. Latham Scientific Engagement Fellowship (2016)

1. Fight for Sight Summer Student Fellowship (2015)

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