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Christopher Reinhardt

BSc Chemistry & Biology, State University of New York at Buffalo


PhD Student in Chemistry (Chemical Biology)


Pines Graduate Fellow


14. Yadav AK, Lee MC, Lucero MY, Reinhardt, CJ, Su S, Chan J. NIR bioluminescence probe enables discovery of diet-induced modulation of tumor microenvironment via nitric oxide. ACS Cent. Sci. 2022, 8, 461.

13. Lucero MY, East AK, Reinhardt CJ, Sedgwick AC, Su S, Lee MC, Chan J. Development of NIR-II photoacoustic probes tailored for deep-tissue sensing of nitric oxide. J. Am. Chem. Soc. 2021, 143, 7196–7202.

12. Gardner SH, Reinhardt CJ, Chan J. Advances in activity-based sensing probes for isoform-selective imaging of enzymatic activity. Angew. Chem. Int. Ed., 2021, 60, 5000–5009.

11. Zhou EY, Knox HJ, Reinhardt CJ, Partipilo G, Chan J. Near-infrared photoactivatable nitric oxide donors with photoacoustic readout. Methods in Enzymology, 2020, 641, 113-147.

10. Yu ZH, Reinhardt CJ, Hin-Fung T, Chan J, Au-Yeung HY. Activity-based ascorbate sensing using a copper-mediated oxidative bond cleavage. Chem. Eur. J.2020, 26, 8794-8800.

9. Reinhardt CJ, Xu R, Chan J. Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform. Chem. Sci. 2020, 11, 1587-1592.

8. Yadav AK, Reinhardt CJ, Arango AS, Huff HC, Dong L, Malkowski MG, Das A, Tajkhorshid E, Chan J. An activity-based sensing approach for the detection of cyclooxygenase-2 in live cells. Angew. Chem. Int. Ed. 2020, 59, 3307-3314.

7. Bothwell IR, Cogan DP, Kim T, Reinhardt CJ, van der Donk WA, and Nair SK. Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics. PNAS. 2019, 116, 17245-17250.

6. Zhou EY, Knox HJ, Reinhardt CJ, Partipilo G, Nilges M, and Chan J. Near-infrared photoactivatable nitric oxide donors with integrated photoacoustic monitoring. J. Am. Chem. Soc. 2018, 140, 11686-11697.

5. Zhai X,  Reinhardt CJ, Malabanan MM, Amyes TL, and Richard JP. Enzyme architecture: Amino acid side chains which function to optimize the basicity of the active site glutamate of triosephosphate Iisomerase. J. Am. Chem. Soc. 2018, 140, 8277-8286. 

4. Reinhardt CJ, Zhou EY, Jorgensen MD, Partipilo G, and Chan J. A ratiometric acoustogenic probe for in vivo imaging of endogenous nitric oxide. J. Am. Chem. Soc. 2018, 140, 1011-1018.


3. Reinhardt CJ and Chan J. Development of photoacoustic probes for in vivo molecular imaging. Biochemistry. 2018, 57, 194–199. 


2. Richard JP, Amyes TA, Malabanan M, Zhai X, Kim KJ, Reinhardt CJ, Wierenga RK, Drake EJ, Gulick A. Structure-function studies on hydrophobic residues that clamp a basic glutamate side-chain during catalysis by triosephosphate isomerase. Biochemistry 2016, 55, 3036-3047.


1. Reyes AC, Zhai X, Morgan KT, Reinhardt CJ, Amyes TL, Richard JP. The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer and decarboxylation: Specificity and enzyme architecture. J. Am. Chem. Soc. 2015, 137, 1372-1382.


Select Awards

5. Fuson Travel Award (Spring 2020)

4. J.C. Martin Memorial Student Travel Award (2019)

3. Pines Travel Award (2018)

2. ACS Organic Division Undergraduate Award (2015)

1. New York Society of Applied Spectroscopy Undergraduate Award (2015)

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