Concepts in Chemical Biology
CHEM 570 is a graduate-level course.
Enrollment, Late Addition and Auditing Policies
All undergraduates must obtain instructor consent to enroll in CHEM 570. Please note that this course has a limited enrollment capacity, due to the participatory nature of the course. Please see the given link if the class has reached its full capacity when you seek to enroll.
Auditing the class (i.e., attending for no credit) is generally not permitted, again due to the nature of the course. Per Graduate College policy, an auditor is only a listener but does not participate, whereas this course is inherently participatory.
Please take careful note of the CHEM 570 course policies on late addition to the course (Course Policiies link below). Late addition to CHEM 570 (i.e., after the first class session) is strongly discouraged and may be disallowed at instructor discretion.
Final Examination Policies
The university will set the final exam date and time for CHEM 570 (date and time to be announced by the university).
The instructor is not empowered to change this date. Please note that no alternate, "conflict", or early final exam can be offered. Please be sure that your end-of-semester personal schedule allows you to be present for the final exam.
Final exam date: Dec 19, 2017 7-10pm (165 Noyes)
Lecture Presentation Notes
Please print out on your own all lectures (after Lecture 1) and bring them to class
Lecture 1 (August 29) - biochemical basics
Lecture 2 (August 31) - cell biology basics
Lecture 3 (Sept 5) - Analysis of DNA, RNA, and protein levels
Lecture 4 (Sept 7) - Model organisms, genetic KOs, RNAi, and chemical genetics
Lecture 5 (Sept 12) - Fluorescence applications
Lecture 6 (Sept 14) - Imaging probes
Lecture 7 (Sept 19) - Biomolecular interactions / bioconjugation
Lecture 8 (Sept 21) - Combinatorial chemistry
Lecture 9 (Sept 25) - Continued from previous lectures
Lecture 10 (Sept 28) - High-throughput screening
Lecture 11 (Oct 3) - Target identification
Lecture 12 (Oct 5) - Midterm 1 (please arrive 10 mins early)
Lecture 13 (Oct 10) - Unnatural amino acid incorporation
Lecture 14 (Oct 12) - Sequence-specific DNA binders
Lecture 15 (Oct 17) - Activity-based protein profiling
Lecture 16 (Oct 26) - Molecular basis of cancer
Lecture 17 (Oct 26) - Anti-cancer agents
Lecture 18a (Oct 31) - Stem cells and regenerative medicine
Lecture 18b (Oct 31) - Phage display and yest hybrid
Lecture 19a (Nov 7) - PTMs: Kinase and phosphatases
Lecture 19b (Nov 7) - PTMs: Transglycosylation and glycosidases
Lecture 20 (Nov 9) - Midterm 2 (answer key)
2016 Exams (for practice)
Literature Manuscripts for in-class discussions
Please print out and critically read EACH of the listed manuscripts IN ADVANCE OF the indicated lecture. You should be ready to participate in the classroom discussion for each of the manuscripts. The student presentation schedule is posted via a link near the top of this webpage.
Student-led discussion presentations
Student Research Projects
Please note: all papers should be 1.5 line spacing with 1-inch margins and use 10-point Arial font.
Presentation schedule (presentation dates November 8, 10, 15, 17 and December 1) - available later in semester