Hailey, Tom and Beth's paper is accepted for publication in ACS Chemical Biology!
March 6, 2018
Photophysical tuning of N-oxide-based probes enables ratiometric photoacoustic imaging of tumor hypoxia
Hypoxia results when oxygen supply to rapidly growing tumors becomes inadequate to support various physiological processes. This plays a role in tumor metastasis and treatment resistance. Identifying tumor hypoxia can therefore guide treatment planning and predict patient responses. However, hypoxic volumes are heterogeneously dispersed throughout a tumor, making it a challenge to pinpoint them with any degree of accuracy. Herein, we report the development of ratiometric hypoxia probe 1 (rHyP-1), a hypoxia-responsive small-molecule probe designed for reliable hypoxia detection using photoacoustic imaging. Photoacoustic imaging utilizes NIR light to induce the production of ultrasound signals, enabling high-resolution image acquisition at centimeter depths. Together with the ratiometric capability of rHyP-1, reliable hypoxia detection with unprecedented spatial resolution is possible while minimizing error associated with concentration dependence and tissue heterogeneity.
Chris successfully defended his thesis!
June 19, 2020
Anuj and Chris's paper is published in Angewandte Chemie!
December 18, 2019
Effie, Hailey, and Chris's book chapter is accepted for publication in Methods in Enzymology!