April 23, 2020

Hailey successfully defender her PhD thesis! After leaving UIUC, Hailey will be heading to Caltech to start a postdoctoral research position with Prof. Dennis Dougherty. Congratulations Hailey! 

Thesis title: Development of Small-Molecule Probes for Photoacoustic Imagin...

April 4, 2020

 Advances in activity-based sensing probes for isoform-selective imaging of enzymatic activity

The cell regulates complicated signaling and metabolism through strict transcriptional, translational, and post-translational regulation. Considerable advances have been achie...

March 10, 2020

Chelsea successfully defended her PhD thesis! After leaving UIUC, Chelsea plans to return to California to begin her next adventure in teaching chemistry. Congratulations Chelsea, we will miss you!

Thesis title: Development of Chemical Tools for Studying Biological...

January 6, 2020

Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform

Nitric oxide (NO) is a key signaling molecule involved in a variety of physiological and pathological processes. Over the past few decades it has become clear that the microenv...

January 3, 2020

A photoactivatable formaldehyde donor with fluorescence monitoring reveals threshold to arrest cell migration

Controlled light-mediated delivery of biological analytes can enable the investigation of highly reactivity molecules within living systems. As many biological...

December 18, 2019

An activity-based sensing approach for the detection of cyclooxygenase-2 in live cells

Cyclooxygenase‐2 (COX‐2) overexpression is prominent in inflammatory diseases, neurodegenerative disorders, and cancer. Directly monitoring COX‐2 activity within its native environmen...

December 5, 2019

Lukas successfully passed his PhD defense and became the very first Chan Lab member to complete his PhD! After leaving UIUC, Lukas plans to return home to Germany and start his next big adventure. Congratulations Lukas, we will miss you!

Thesis title: Development of Che...

November 18, 2019

Rational Design of a Red Fluorescent Sensor for ALDH1A1 Displaying Enhanced Cellular Uptake and Reactivity

High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. To facilitate the...

November 18, 2019

Three Chan Lab undergrads presented their research at the 2019 ECI ACS Undergraduate Research Conference. Irian was selected to present an oral presentation and gave an outstanding talk, and Douglas and Lupe both received outstanding poster awards for their poster pres...

October 29, 2019

A Conformationally Restricted Aza-BODIPY Platform for Stimulus-Responsive Probes with Enhanced Photoacoustic Properties

Photoacoustic (PA) dyes, which absorb near-infrared (NIR) light to generate an ultrasonic signal, can be detected at centimeter depths in tissues with...

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